Where everyone belongs in the ring.
321 Knockout is an exciting new community fitness challenge and fundraiser bringing together individuals with Down syndrome, caregivers, siblings, and community members for a morning of movement, fun, inclusion, and connection. All abilities are welcome.
Take the Challenge & Sign the Commitment
Volunteer for 321 Knockout on Aug 8
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Three chromosomes
Trisomy 21 — three copies of the 21st chromosome that make every one of our athletes extraordinary.
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One movement, doubled
Two months of community prep — June & July — building strength together before the big day.
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One powerful community
Punches for possibilities. Knocking out barriers. One event, one purpose, one family.
Get Ready - Start NOW
The challenge is in August — but the journey starts now. Join our community prep period and build your strength, confidence, and team spirit alongside hundreds of Arizona families.
June - Ignite your training
Join Down to Box or one of our community partner adaptive fitness programs. Meet and connect with other families preparing for the challenge.
July - Build your momentum
Ramp up your fitness routine, open your fundraising page, and rally your supporters. Every dollar raised before August amplifies the day.
August 8 - 321 Knockout Day
Show up strong. Cheer loud. Punch for possibilities alongside 100 athletes, 250+ families, and a community built all summer long.
100 athletes in action
Individuals with Down syndrome and community members participate in timed rounds.
9 activity stations
Fun, interactive challenges hosted by community sponsors — keeping athletes moving and engaged.
The 321 Boxathon
High-energy punch rounds where supporters donate $1 per punch — building excitement and real impact.
Sideline energy & prizes
200+ cheering, plus raffle prizes, awards, and cool giveaways from community partners.
Movement is Essential
Why Fitness Matters
Obesity and weight management are among the most significant health challenges facing individuals with Down syndrome. Low muscle tone, a slower metabolism, and increased risk for heart conditions make consistent movement not just beneficial — but critical for lifelong health and independence.
Structured, supportive fitness programs play a critical role in promoting strength, coordination, mental health, and overall well-being. Movement also builds something less visible but just as important — social connection, confidence, and a sense of belonging that carries into every part of life.
DSNetwork and its partners offer a wide range of programs designed specifically for individuals with Down syndrome, at every age and ability level. 321 Knockout funds access to those programs for every family who needs them.
Summer 2026 Training Opportunities (click the links below)
Where your support goes.
Every punch funds something real.
All proceeds from 321 Knockout directly support DSNetwork’s Adaptive Fitness & Wellness Initiatives — programs and partnerships designed to build strength, confidence, and a sense of belonging for individuals with Down syndrome across the lifespan.
Adaptive fitness equipment designed for diverse physical abilities
Trained instructors with expertise in Down syndrome health and wellness
Inclusive fitness and wellness programs that build strength, coordination, and confidence
Opportunities for social connection and belonging through shared movement
Consistent, year-round programming that promotes long-term health and independence
Stronger families and community connections through accessible, supportive environments
C.J. Udall Scholarship Fund
A portion of every dollar raised funds the DSNetwork C.J. Udall Scholarship Fund — ensuring that no family is turned away from programming due to financial need. Access to fitness and wellness shouldn’t depend on a family’s financial situation.