Research and Clinical Trials

Research and clinical trials

clinical trials for down syndrome

Down Syndrome Research

Clinical Research Studies

Barrow Neurological Institute is recruiting individuals to participate in a Down syndrome resear ch study. The study will collect different types of brain scans, including MRI and PET scans, over time to see how Alzheimer’s disease changes the brain. Qualified study participants will receive all studyprocedures at no cost.

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Clinical Trials
Caregiver Support Research Study

Intervention Development for Caregivers of People with DS/IDD and ADRD ~ Arizona State University | College of Nursing and Health Innovations

Dr. David Coon and his team are currently recruiting family members, friends, and professionals to participate in a series of focus groups for caregivers of aging adults with Down syndrome or other developmental disabilities who also have/are experiencing memory loss or memory changes. Qualified study participants will be asked to provide their viewpoints and be compensated for their participation.

Contact: Philip Carll, MSW, Research Consultant
602-496-1239 | PCarll2@cox.net

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Advocate Medical Group

The Adult Down Syndrome Center is one of eleven sites working together to carry out clinical trials more rapidly. The initial focus is aimed at preventing Alzheimer’s disease onset in people with Down syndrome as well as supporting relevant observational studies.

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Down Syndrome Research

Sleep Apnea

• Medications for Obstructive Sleep Apnea in Children with Down Syndrome
o Interventional | Not yet recruiting
 Age: 6-17 years | Location: University of Arizona | Tucson, AZ
 Interventions: Drug – Atomoxetine and oxybutynin (ato-oxy)
 Study Description: This is a randomized, double blind, cross-over study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with DS and OSA documented by polysomnography (PSG).
Learn more https://clinicaltrials.gov/ct2/show/NCT04115878

Dual Diagnosis of Down Syndrome and Autism Spectrum Disorder

• SPARK: sponsored by the Simons Foundation Autism Research Initiative, has the mission of speeding up research and advancing understanding of autism by building the nation’s largest autism study. https://www.sfari.org/
o You can register online and contribute a saliva sample using a collection kit from your home.
o Individuals with autism will receive gift cards valued up to a total of $50 for participating.
o Registration and information can be found online at www.SPARKforAutism.org/BCH.

Genetics

• Study of Blood Samples from Newborns with Down Syndrome
o Observational | Active, Not Recruiting
 Age: Up to 90 days
 Location: Phoenix Children’s Hospital, Phoenix, AZ
 Trial Description: This research study is looking at blood samples from newborns with Down syndrome. Studying the genes expressed in samples of blood from patients with Down syndrome may help doctors identify biomarkers related to cancer.

Learn more https://clinicaltrials.gov/ct2/show/NCT00959283

Alzheimer's (1 of 2 Studies)

Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults with Down Syndrome

  • Interventional | Active, Not Recruiting
  • Age: 25-45 years
  • Location: St. Joseph’s Hospital and Medical Center-Barrow Neurology Clinics, Phoenix, AZ

Trial Description:
The purpose of this study is to test in adults with Down Syndrome the safety, tolerability and immunogenicity of a vaccine, ACI-24.

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Alzheimer's (2 of 2 Studies)

Study of Alzheimer’s Disease in Down syndrome

  • Observational | Recruiting
  • Age: 25+
  • Location: Barrow Neurological Institute, Phoenix, AZ 85013
  • Contact: Sandy Quintanilla | 602-406-7054 | sandy.quintanilla@dignityhealth.org
  • Principal Investigator: Anna Burke, M.D.

Trial Description: This is an observational, multi-center, longitudinal cohort study to characterize adults with Down syndrome ages 25 years and above enrolled at specialized care centers. The aim is to assess changes in cognition, behavior, function and health over approximately 24 months. Blood will be collected for the development of plasma AD biomarkers useful in the Down syndrome population.

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Down Syndrome Research

Leukemia (1 of 3 Studies)

B-Lymphoblastic Leukemia

  • Study to investigate Blinatumomab in combination with Chemotherapy in Patients with newly Diagnosed B-Lymphoblastic Leukemia
  • Interventional | Recruiting
  • Age: 365 days to 31 years
  • Locations:
    Cardon Children’s Medical Center, Mesa, AZ, Phoenix Children’s Hospital, Phoenix, AZ, Banner University Medical Center, Tucson, AZ

Trial Description: This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome.
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Leukemia (2 of 3 Studies)

Acute Myeloid Leukemia

  • Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients with Down Syndrome
  • Interventional | Recruiting
  • Age: 91 days to 3 years
  • Locations: Cardon Children’s Medical Center, Mesa, AZ, Phoenix Children’s Hospital, Phoenix, AZ

Trial Description: This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome.

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Leukemia (3 of 3 Studies)

Risk-Adapted Chemotherapy

  • Risk-Adapted Chemotherapy in Treating younger patients with newly diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma
  • Interventional | Active, Not Recruiting
  • Age: 1-30 years
  • Locations: Cardon Children’s Medical Center, Mesa, AZ, Phoenix Children’s Hospital, Phoenix, AZ, Banner University Medical Center, Tucson, AZ

Trial Description: This partially randomized phase III trial studies the side effects of different combinations of risk-adapted chemotherapy regimens and how well they work in treating younger patients with newly diagnosed standard-risk acute lymphoblastic leukemia or B-lineage lymphoblastic lymphoma that is found only in the tissue or organ where it began (localized).

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